This study was conducted to find out the etiology of all granulomatous lesions on Histo-pathology and Cytological studies. Our study was done at MGM Medical college, Kamothe, Navi Mumbai 4 years (2012-2015) . All the cases which were clinically diagnosed and suspected of granulomas, on haematoxylin and eosin stained sections were studied. Special stains like ZiehlNeelsen stain, PAS stain and FiteFaraco stain were done whenever required. The morphological features and special staining helped us to find the specific etiology of Granulomas in 86 cases whereas it could not be determined in 14cases even after special stains. The most common etiology of granuloma in our study was tuberculosis (49cases) followed by leprosy in 15 cases and no specific etiology in 16 cases. This may be due to reason India is a tropical country and tuberculosis is a leadinginfection In our study 25 cases FNAC was done and correlation was found in 18 cases. Hence FNAC is adjuvant to diagnose granulomatous lesion
