The spine is very delicate structure of the human body. The spinal cord is located inside the spine. Vertebrae are small bone forming the spinal column. Human spine has natural “S” curve. These curves round our shoulders and make our lower back curve slightly inward. Spine has three slight curves one in the neck, one in the upper back, and another in the lower back. These curves are normal and can be seen from a side view. From a back view, spine should appear straight. If a spine have side to side curve the curve is called scoliosis. The curve may be very small (mild). It may be bigger (moderate). Or it may be sharp (sever). Scoliosis is present in 0.2 – 6% of the population, affecting females in most cases. Scoliosis affects Young girls engaged in rhythmic gymnastics, swimmers, professional musicians and dancers. The gathering of all the genetic data on spinal cord disorders, then a comparative analysis was performed on the various types of genes and their biological factors which are the likely to cause scoliosis in either mutant or deficiency forms. The q-arm contributes to scoliosis disorder than the p-arm. Scoliosis is prevalence among most active group between 18-70 years.