Analytical Method Development And Validation For The Simultaneous Estimation Of Dutasteride And Granisetron

During treatment of cancer by chemotherapeutic agents one of the major side effect is induction of emesis in patients. There is always need of simultaneous administration of antiemetic drugs while patients on chemotherapeutic treatment. So there is necessity to develop methods for simultaneous estimation of anticancer and antiemetic. In this work simple, accurate, precise method for the simultaneous estimation of dutasteride (anticancer) and granisetron (antiemetic) was developed and validated by UV-visible spectroscopy using solvent methanol: water. Maximum absorption shown by dutasteride is at 246 nm whereas for granisetron it is 306 nm. The validation of uv-visible spectroscopic methods was carried out in accordance with ICH guideline.