Termiticidal effect of methanol, aqueous and hexane solvent leaves extract of Argemone mexicana were studied against Odontotermes obesus. The plant leaves were dried, powdered and extracted with methanol, aqueous and hexane solvent in soxhlet apparatus for 24 hrs. The 10 termites were exposed to various concentrations (2.5, 5.0, 7.5, 10.0, 12.5 and 15 mg/ml) of methanol, aqueous and hexane plant extract of Argemone mexicana and percent mortality were recorded after 24 hrs. The termiticidal activity of leaves extract of Argemone mexicana were (LD10= 5.162 mg/ml, LD50= 10.44 mg/ml) in methanol, (LD10= 5.604 mg/ml, LD50= 12.17 mg/ml) in aqueous solvent and hexane (LD10= 7.665 mg/ml, LD50= 11.55 mg/ml) respectively. Results revealed that the mortality was increased with increasing in concentration of the plant extracts. The methanol solvent extract of Argemone mexicana showed higher termiticidal property against Odontotermes obesus. Statistical variance, 95% confidence limits and regression equations are presented.