Induction: Infection of soft tissue is a common complication of any surgical procedure. on the part of both the patient's bacterial flora and the environmental bacterial flora. It has an incidence that ranges from 10.6% to 22.2% depending on the type of intervention; a considerable part of the infections were observed after discharge Materials and methods: The study was performed between October 2012 and January 2016. Patients undergoing invasive procedures and diagnostic procedures were included for various indications in the departments of both clinical surgery II and Catania AOU surgery. Both urine samples for microscopy and cultures in all patients were collected and collected at hospitalization prior to both diagnostic and therapeutic procedures. Two subsequent blood cultures were performed in patients, with a 30-minute interval between them, 1 hour after the procedure. The sample recruited for the study included a total of 160 patients, of which 96 (60%) male and 64 (40%) female. The average age of patients was 52.5 years (range 20-85 years) Results: In our study, we found one of significant bacteriuria after cystoscopy only in 10-12% of the observed cases. Urine culture detected before the procedure and intervention highlighted the need for antibiotic prophylaxis that was found to be effective on Escherichia coli strains isolated in urine, which had multiple antimicrobial resistance producing broad-spectrum beta lactamases (ESBL). Conclusions: In the diagnostic and therapeutic procedures of contaminated clean and clean surgery, a single dose of prophylaxis is confirmed to be effective in reducing the risk of infection after a careful analysis of the patient. In the contaminated surgical procedures, the antibiotic therapy must be reasoned. and to have the anamnestic data, the immunological profile, in addition to the microbiological data of the most widespread bacteria in the hospital where it operates, before being able to proceed with specific therapeutic treatment in order to prevent the infectious risk with the most effective antibiotic programming of the infectious agent that infection
