Antimicrobial properties of aqueus extracts of 6 different plant extracts were tested against bacterial pathogens such as Staphylococcus aureus and Pseudomonas species. The determination of the antibacterial activity by agar well diffusion method and Disc diffusion method showed that 6 plant extracts tested exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas species. The present experimental results indicated that out of 6 crude extracts from different plant species Chromolaena odorata, Tectona grandis, Musa paridisiaca, Hemigraphis colorata, Curcuma longa and Psidium guajava possessed antimicrobial activity against Staphylococcus aureus and Pseudomonas species. Phytochemical screening of selected plants showed the presence of Saponin, Proteins, Tannins, Flavanoids, Steroids and reducing sugars. The above observations confirmed that some of these plant extracts possess bactericidal compounds, which inhibit the growth of Staphylococcus aureus and Pseudomonas species.