Ziziphusjujuba L. commonly known as Ber in Pakistan, belonged to the family Rhamnaceae that consists of 45 genera and 550 species is widely distributed in tropical and subtropical climates in the world. Ziziphusjujuba L is a hardy tree of arid region which can be grown successfully in saline soil under hot, arid environment. Its fruits are palatable and delicious with a good amount of vitamin A, C and B complexes and minerals. The present study was to evaluate in-vitro antiinflammatory activity of Ziziphusjujuba fruit. The aim of the present studies was carried out in the following objectives to determine the antioxidant and anti-inflammatory activity of PFZjF extract. The results showed that the DPPH and NO radical scavenging activity increased in concentration dependent manner of PFZjF extract when compared to standard ascorbic acid respectively. The PFZjF extract showed significant anti-inflammatory activity was observed at 30 µg/ml when compared to control 39 µg/ml of Diclofenac sodium respectively. Denaturation of proteins is a well-documented cause of inflammation. From the results of present study it can be stated that the extracts of PFZjF extract are effective in inhibiting heat induced albumin denaturation. The PFZjF extract can be recommended as a potent anti-inflammatory drug which can be used for treatment of numerous diseases.
