Assessment Of Left Ventricular Systolic And Diastolic Function In Subclinical Hypothyroidism

Research Article
Velkoska Nakova V, Krstevska B, Srbinovska Kostovska E, and VaskovaO
Subclinical hypothyroidism, left ventricular function, systolic function, diastolic function, echocardiography

Objective: Studies investigating systolic and diastolic left ventricle function in subclinical hypothyroidism (ScH) have shown controversial results. As myocardium is a target organ of thyroid hormone action, the aim of the study was to assess the left ventricular systolic and diastolic function in ScH.

Methods: Fifty-four patients with newly diagnosed ScH and 30 euthyroid controls, patients of the University Clinic of the Endocrinology, Diabetes, and Metabolic Disorders Clinic were enrolled. Transthoracic echocardiography, using M-mode, two-dimensional (2D), pulsed, continuous and color-Doppler, and advanced echocardiographic modalities Tissue Doppler and two-dimensional speckle tracking was performed in all subjects.

Results: Although normal echocardiographic values of all measured parameters, SCH patients were significantly different from their matched controls: the ratio between E/A was statistically significantly lower (1,26±0,36 vs. 1,03±0,29, p<0,01), the ratio between Е/е’ sep. was statistically significantly higher (6,04±1,64 vs. 7,62±2,29, p<0,01), MPI was statistically significantly higher (0,43±0,07 vs. 0,47±0,08, p<0,05), GLS had statistically significantly lower negative value (-20,9±1,7 vs. -19,55±2,3%, p<0,001), and S/TDI was statistically significantly lower (0,092±0,011 vs. 0,077±0,013, p<0,01). TSH negatively correlated with EF (r=-0,15, p<0,05), E/A(r=-0,14, p<0,05), GLS (r=-0,26, p<0,001), S/TDI (r=-0,22, p<0,01), and positively correlated with E/e 'sep. (r=0,14, p<0,05).

Conclusion: Subclinical hypothyroidism contributes to changes in certain parameters involved in the assessment of global and longitudinal systolic and diastolic left ventricular function compared to healthy individuals.