Azadirachta indica seed extract has been shown to have antihyperglycemic and antihyperlipidemic effect as per earlier report of traditional medicine used by native people of Africa origin. In the present study, antihyperglycemic and antihyperlipidemic effect of Azadirachta Indica (family, Meliaceae) seed was evaluated in adult albino rat. Methanol extract (ME) and fractions (PEF, MF) were administered orally at the doses of 100,500,1000mg/kg body weight for duration of 30 days, and 0.5ml/kg of 3% tween 80 was administered to control group. There was significant reduction (P<0.05) in fasting blood glucose and total cholesterol levels compared to baseline and control. The reduction was not in a dose related manner. It is concluded that Azadirachta indica may have beneficial effect as antihyperglycemic and antihyperlipidemic agent of future.
