The rapid development of dental biomaterials necessitates a comprehensive understanding of current trends and their impact. Conducting a bibliometric analysis becomes crucial to identify key research directions, influential researchers, and significant contributions in this dynamic field. Such insights will guide evidence-based decisions, foster collaborations, and shape the future of dental biomaterials for improved patient care and clinical outcomes. This study aimed to conduct a comprehensive bibliometric analysis of calcium-enriched mixture (CEM) cement as an endodontic biomaterial in dental literature. A comprehensive search of the Scopus database was performed using relevant keywords. The data collection period extended from 2010-2023. The collated data underwent thorough analysis to delineate publication trends, source distribution, document types, subject areas, geographical distribution, authorship, keywords, and citation impact associated with CEM cement research. The analysis demonstrated a marked rise in scholarly interest in CEM cement since 2010, with a peak noted in 2016. The "Iranian Endodontic Journal" surfaced as a significant platform for CEM cement research. Original research articles constituted the majority of the documents, emphasizing the value of primary research in this field. Although dentistry was the prevalent subject area, contributions were also discernible in fields such as medicine/materials science. Geographically, Iran led in terms of research contributions, followed by the USA. Prominent researchers' participation further underlined the scientific influence and specialized knowledge in this field. Keyword analysis provided insights into prevailing research themes, including endodontics and material properties. This analysis yielded valuable insights into the evolving research landscape of CEM cement in dental literature; it can inform/guide future research directions/collaborations in dental biomaterials science.