Background: Triple therapy (Proton Pump Inhibitor+Claritromycin+Amoxycillin or Metronidazol) is widely used throughout the world against Helicobacter pylori. Eradication rates in due course after use of the triple antibiotics therapy were investigated. Methods: Data of 1000 patients who received the standard therapy between 2000 and 2010 and after 2010 were selected for the study; they were administered PPI, claritromycin 500 mg BID, Amoxycillin 1 g BID for 14 days and the eradication of Helicobacter pylori has been verified using urea breath test after six weeks starting from the cessation of the therapy. 500 patients have got the therapy before 2010; 500 of them were treated after 2010. The decrease in Helicobacter pylori eradication rate after using the standard triple therapy has been discussed. Results: Retrospective analysis of data from 1000 patients was made. 608 patients (60.8%) had gastric problems except ulcer and 192 patient (19.2%) had duodenal ulcers. During the period between 2000 and 2010, 412 patients (82.4%) got successful Helicobacter pylori eradication treatment; for the period after 2010, 262 patients (52.4%) were successfully treated. Statistically significant difference was found between the groups in terms of Helicobacter pylori eradication results (p <0.001). Conclusions: In this study it was stated that the eradication rate has been observed in due course was below 80% which is the recommended treatment goal. Despite differences existing between regions in terms of the reponse to the therapy quadruple therapy including bismuth should be considered as the first choice
