Oral cancer is most common cancer in males and third most common in females, the main causative agent being use of chewing betel quid (BQ). Areca nuts, Catechu, Slaked lime are major components of Betel quid. Nitrosamines formed from alkaloids in betel nut during betel quid chewing may be implicated in the etiology of oral cancer. In this present study cases were screened from Department of E.N.T. & Oral and Maxillofacial surgery of Ramakrishna Mission Seva Pratishthan Hospital, Kolkata and different areas of West Bengal. Some of them had more than one addiction and some have no addiction and complications. Mitotic index are higher in cancer and pre cancer (both betel quid and non betel quid chewers) cases than normal. Percentage of chromosomal aberration (CA) is higher in cancer cases.
