Cleft lip and/or palate fall within the most common congenital abnormalities of the craniofacial region. There are a lot of phenotypes and clinical features of this malformation, which differ according to the different anatomical structures involved. The etiology is multifactorial, genetic and environmental conditioned, and not already known. To provide a correct diagnosis and treatment is necessary a multidisciplinary study and intervention, that is why is really important the presence of a clinical team to solve this pathology. The interaction between different clinical professional figures guarantee an adequate support for patients and their families. The surgical treatment is the most common treatment use for this pathology, together with the orthodontic treatment. However today the optimal treatment is difficult to find because of the large variability of this pathology and the subjective response of each patient to the therapy.