Clinical Implications And Immunological Findings Of Perthes Disease: Review

Perthes disease occurs in children between the age of 5-15 years and is characterized by varying degrees of idiopathic avascular necrosis of the upper femoral epiphysis. It is followed by spontaneous revascularization occurring over a period of time, i.e. 1.5 to 3 year during which period the femoral head is at the risk of deformation. This disease is due to various predisposing factors i.e. genetic, abnormal growth and development, environmental factors, trauma, transient synovitis, abnormal venous damage & arterial block and infarction. In view of this, various immunological aspects are considered to deliberate on unknown aetiology of perthes disease.