Background: The role of virus in the etiology of periodontitis has long been understood. Human cytomegalovirus has been postulated to be associated with periodontitis. The role of HCMV in initiation and progression of periodontitis has been demonstrated by Conterars and Slots. Immunoglobulin G [IgG], Immunoglobulin M [IgM] are two antibodies produced by human body against HCMV. IgG is formed and elevated during active infection, whereas IgM is elevated during their initial infection stage. In this study we compared and evaluated the serum titres of IgG, IgM against HCMV in Gingivitis, Chronic periodontitis, Aggressive periodontitis before and after scaling and root planing. Aim: To evaluate the serum titres of antibodies viz; Immunoglobulin G [IgG], Immunoglobulin M [IgM] against HCMV in three Groups of Gingivitis, Chronic periodontitis and Aggressive periodontitis patients before and after Scaling and Root planing [SRP]. Materials & Methods: Thirty subjects were assigned in to three groups, Group A [Gingivitis], Group B [Chronic Periodontitis], Group C [Aggressive periodontitis] with ten subjects in each group. All clinical parameters like Gingival Index [GI], Plaque Index [PI], Probing Pocket Depth, Clinical Attachment Level & biochemical parameters like serum titres of IgG, IgM antibodies levels were evaluated at baseline and three months after SRP. Results: The present study showed a significant reduction in mean values of IgG with a greater significance in Group C. There is no significant reduction in IgM values of Group A than Group B & C. Conclusion: Within limitations of the study, there is a significant relation of viral titres and periodontal diseases. An increase in IgG values before SRP and their value reduction after SRP showed the positive correlation of viral titres and periodontitis
