Background: Periodontal diseases are localized to the immediate environment of pocket making the pocket a natural site for treatment with local sustained delivery systems. Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes.
Aim and objectives: The aim of the present study was to evaluate the efficacy of the adjunctive use of minocycline plus scaling / root planing as compared with scaling / root planing alone in the treatment of the chronic periodontitis and to compare the effects of local drug delivery of minocycline microspheres as an adjunct to scaling and root planing with scaling and root planing alone.
Materials and Methods: A total number of 72 sites from 18 patients were selected for the study who had periodontal pockets measuring ≥5 mm and had been diagnosed with chronic periodontitis, were selected for the study. The selected groups were randomly assigned to either the control group (group I) or the treatment/test group (group II). Only scaling and root planing were done at the base line visit for the control sites and for test sites scaling and root planing were done at the base line visit followed by local application of Arestin™ (1 mg) and reapplication of Arestin™ (1 mg) was done on 30th day. Clinical parameters such as plaque index, gingival index, and gingival bleeding index were recorded at baseline, day 30, day 90, and day 180 in the selected sites of both the groups. Probing pocket depth and Clinical attachment level also was recorded at baseline, day 90, and day 180 for both the groups.
Results: A statistically significant reduction was observed in both groups. Group II showed statistically significant reduction in all the clinical parameters than Group I (p<0.001).
Conclusion: The results of this study confirm that Arestin (1mg Minocycline microspheres) delivered in biodegradable system, are a safe and efficient adjunct to scaling and root planing, and can produce significant clinical benefits when compared to scaling and root planing alone
