Aim of this work was a comparative study of anthelmintic activity of albendazole nanoemulsion containing oregano essential oil with a marketed formulation.. A problem stated with the use of synthetic anthelmintics is the development of parasitic resistance, which threaten the success of treatment in humans, use of a herbal alternative may reduce such resistance .Essential oil of Oreganum vulgare when taken orally kills intestinal parasites, therefore it can enhance the action potential of anthelmintics. Nanoemulsion containing drug and oregano essential oil (NEO) was prepared. And its various evaluation studies were done. The formulated product and marketed product was then evaluated in artificial laboratory conditions by using the earthworms (Lumbricusterrestris). Various parameters such as mean paralytic time, mean death time, drug content, invitro drug release studies of both were done. The formulate nanoemulsion had shown a highly better action than that of the marketed product. This study suggest that nanoemulsion is a promising novel formulation that can enhance the solubility of poorly soluble drug like albendazole and thereby enhance its oral bioavailability
