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This study aims to examine theoretical coping model as a mediator of optimism roles and family resilience to subjective well-being in mothers with intellectually disabled children. Subjects/respondents in the study were 210 mothers who had children with intellectual disability with the last minimum education junior high school. The variable on this study is subjective wellbeing, coping, optimism and family resilience. The validity and reliability of the whole scale used confirmatory factor analysis (2nd Order CFA). Structural Equation Model (SEM) with LISREL (Linear Structural Relation) program was used as the analysis of research data. The results of the data analysis show that major hypothesis of "theoretical model of coping as mediator of optimism role and family resilience to subjective well-being in mothers with intellectually disabled children is a fit model with the empirical data". The result of hypothesis test shows that: 1) there is optimism role toward subjective well-being but there is no role of family resilience to subjective well-being, 2) there is role of optimism and family resilience with mediation of coping to subjective well-being