Objectives: To study the correlation of C-reactive protein (CRP) with severity of diabetic retinopathy (DR) in patients with type II diabetes. Methods: This prospective, cross sectional study consisted of hundred patients with DR (classified by using Early Treatment Diabetic Retinopathy Study, ETDRS) who were examined as in keeping with the predesigned proforma. Precise ophthalmological examination was done; fasting and postprandial blood sugar (FBS and PPBS), Glycosylated hemoglobinHbA1C, CRP and serum lipid profile, serum creatinine and uric acid had been assessed. Results: The present study showed that CRP ranges have statistically significant correlation with DR and also full-size association between increasing lipid levels and DR (p<0.05) was seen. Serum LDL stages and triglycerides additionally confirmed statistically good sized correlation with growing severity of DR. Conclusion: CRP may be relied as a watchdog biomarker for progression of DR, also persistently deranged lipid profile may be targeted for purpose of remedy, in known diabetics for prevention of advanced DR
