Development And Validation Of Spectroscopic Method For Simultaneous Estimation Of Paliperidone And Olanzapine In Syenthetic Mixture

A simple, specific, accurate, precise and economical spectrophotometric method has been developed for the estimation of Paliperidone and Olanzapine in synthetic mixture. The absorption maxima of the drugs were found to be 269nm and 259nm for Paliperidone and Olanzapine respectively. Paliperidone and Olanzapine obeyed beer’s law in the concentration range 3-18 µg/ml and 2-12 µg/ml respectively. Different analytical parameter such as linearity, precision, accuracy, limit of detection (LOD), limit of quantitation (LOQ), were determined as per ICH guidelines. Hence, the developed method can be used quality control analysis.