Background: Hepato-cellular Carcinoma (HCC) is a serious disease that is consistently increasing among the population of third world countries. Due to scarcity of tools to detect HCC at an early stage it is resulting in high morbidity and mortality. This study was planned to bring a new method for early diagnosis of HCC. Objective: To determine the diagnostic accuracy of Transient Elastography for the early detection of HCC in viral etiology related liver cirrhosis keeping Dynamic Computed Tomography as a gold standard. Methods: This was a cross sectional study carried out for a duration of six months, from 21st September 2015 to 21st March 2016, in Centre for Liver and Digestive Disease (CLD), Medical Unit 1, Holy Family Hospital, (HFH) Rawalpindi, Pakistan. Patients with diagnosis of cirrhosis secondary to HBV and HCV were enrolled for this study irrespective of their age and gender. Detailed history, physical examination and biochemical measurements were recorded. Patients underwent Transient Elastography and Dynamic Triphasic CT scan to see HCC. Results: Hundred and forty-four patients fulfilling the inclusion criteria were included in this study. There were 79 (54.9%) males and 65 (45.1%) females. The mean ± standard deviation age of study population was 44.01± 10.270 years. On analysis of demographicdata, it was observed that 73 (50.7%) were below 45 years of age & 71 (49.3%) were above 45 years of age. Based on these results, while taking CT scan as the gold standard, the sensitivity of Transient Elastography for diagnosis of HCC was found to be 64.47%, specificity 80.88%, positive predictive value 79.03% and negative predictive value 67.03%. While diagnostic accuracy of test was 72.2% Conclusion: Our study shows that Transient Elastographycan be used as a simple non-invasive test for early identification of HCC in patients with viral etiology cirrhosis.
