The present study supports and prove previous finding that Vitamin A can induce and accelerates lens regeneration in pigmented epithelial cells (PECs) of dorsal iris in Swiss albino mice. In Lens regeneration, many scientist shown that Vitamin A induces the mitogenic activity which causes functional impairment of retinoid receptors and thereby inhibits the lens regeneration. The purpose of present study to understanding the DNA base pair difference between normal lens and regenerated lens DNA. The work was mainly based on histological and molecular aspects of lens regeneration. The study concludes that the base pairs of regenerated lens DNA and normal lens DNA were almost similar except these SNPs. There may be some mutation or aberration of DNA base pair alignment present in regenerated DNA base pair compare to normal DNA base pair.
