Background and objectives: The purpose of this study was to compare the effectiveness of a combination of Trypsin, Bromelain, Rutoside with Diclofenac sodium and a Placebo as a therapeutic agent in impacted mandibular third molar surgery. Method: 90 patients who visited the Department of Oral and Maxillofacial Surgery for surgical extraction of impacted third molars were randomly selected into 3 groups for a double blinded study to compare the effectiveness of Tribolin, Diclofenac sodium and a Placebo. Parameters like pain, swelling and mouth-opening were assessed at specific intervals postoperatively. Results: Combination of Tribolin was more effective for the said parameters when compared to use of the Diclofenac Sodium or the Placebo. The mean value of trismus was more in Diclofenac sodium than Tribolin and mean value of pain was more in the Placebo group when compared to Tribolin and Diclofenac sodium. Conclusion: Our study suggested that a combination of Tribolin and Diclofenac sodium was more effective in reducing post-operative pain, swelling and improve inter-incisal mouth-opening following removal of mandibular third molar surgery. While assessment of Swelling, Tribolin exhibited an increase when compared to the other 2 groups. In the assessment of Pain, we found that Placebo exhibited more pain than the other two groups and as for Trismus Diclofenac sodium exhibited more when compared to Placebo and Tribolin.
