Background and objectives: Lp (a) concentrations shows considerable variation in healthy individuals and is one of the strongest genetically determined risk factor for development of cardiovascular disease. People with T2DM have 2-4 fold increase in the risk of developing cardiovascular disease. The possibility that T2DM could influence Lp (a) concentrations has been investigated in past, but the results have been controversial and inconclusive. The purpose of the present study was to measure Lp (a) levels in patients with T2DM and to see that whether there is any correlation with glycemic control and lipid profile in North Indian population. Method: A cross sectional study was conducted on 41 patients with T2DM and 41 age and sex matched healthy controls. Samples were drawn to analyze Lipids, Lp (a)and HbA1c. The data obtained was statistically analyzed using SPSS version 20. Mean and SD for all parameters were calculated between patients and controls using unpaired t test. Correlation between Lp (a) levels and HbA1c and lipids was tested using nonparametric Spearman’s correlation formula. P value (2 sided) of <0.05 was considered significant. Result: No significant difference was observed in the level of Lp (a) in patients of T2DM (29.26+21.70 mg/dl) and normal controls (26.80+16.89 mg/dl): p value 0.56, although both mean and confidence interval was higher in diabetic group. The values of HbA1c, serum cholesterol and serum triglycerides were significantly higher in Diabetic group (p value <0.05). Analysis of data using the spearman’s correlation coefficient, showed no correlation in value of Lp (a) with HbA1c, cholesterol and triglycerides levels in the study population. Conclusion and interpretation: Lp (a) values do not show any significant association with T2DM and glycemic control in North Indian population of the present study.
