Green synthesis of nanoparticle is gaining more attention of research towards eco-friendly biosynthesis of NPs. In this study, possible role of banana peel extract (BPE) in reducing silver nitrate into silver NPs is highlighted. The biosynthetical NPs were characterized using UV, FTIR, SEM, and XRD. The data revealed that the silver nanoparticle was synthesized after 24-48 hrs of incubation. The UV – VIS surface plasmon resonance peak at 380nm confirmed the Ag+ and AgO ions. FTIR spectra implicate the absorption band at 987.25cm-1 to 3867.39 cm-1in the formation of SNPs.SEM analysis showed 20-50 nm NPs were within the average and mostly spherical in shape. XRD analysis showed 3 peaks at 250, 370, 510, Confirmed the size of the NPs (82nm). The Phytochemical and antioxidant study was confirmed before and after synthesis of Nps. The synthesized NPs was combined with Azithromycin and the drug release study was carried out. 10mg of drug combination gave good drug release study (78%). The antibacterial activity was observed against all pathogens tried which proved the better candidate for pathogens. The BPE NPs showed the 51.75 % of cell death against HeLa Cell Line using MTT assay. The drug coated BPE NPs showed maximum zone of inhibition against E.coli. This recent research suggests the potential application of BPE AgNPs as novel alternative agent in medical application.
