In the present study we evaluated that effect of Aspergillus fumigates infection on the silk gland of Bombyx mori. The fifth instar Bombyx mori larvae was used and inoculated with Aspergillus fumigates inoculum of conidia spore suspension by sprayed on mulberry leafs and fed to silkworms. Mulberry leaves sprayed with distilled water served as control. A pair of silkgland was removed from infected and control group larvae at 72 and 96 hours of post infection and washed with distilled water. The wet weight of the silk gland was measured on an electronic balance, the wet weight of the silk gland was decreased on the 72 and 96 hours of infection when compared with control group. The salivary glands and transverse section of middle silk gland did not exhibit any signs of fungal infection but the cocoon weight was significantly declined following infection over uninfected larvae.
