Stability study of ceftazidime was performed as per ICH guidelines with an emphasis to accelerated, stress and photo degradation of this drug in powder for injection and in solution form after reconstitution. Ceftazidime sample was exposed to simulated accelerated, thermal and photodegradation conditions as observed during hot and humid summer conditions in Indian subcontinent. The samples were analyzed by a pre validated high performance liquid chromatographic method. Results obtained confirmed the photo and thermolabile nature of ceftazidime powder and solution after reconstitution. Thus, an appropriate protection is recommended during storage and handling of this antibiotic after reconstitution such that assay, purity and potency of the drug is maintained.
