The aim of the present investigation is to analyze the mechanism of action of aqueous extract of seeded papaya fruit pulp and seed extract administered as a combined dose and seedless variety papaya fruit pulp extract on fructose constituents in male albino rats. The present study was carried out to assess the effect of semi-ripe fruit pulp extract of Carica papaya (seeded and seedless fruits) on male albino Wistar rats. Fructose content showed a considerable decline in testis and seminal vesicle of both experimental groups. The depletion of seminal vesicle and testicular fructose in rats administered with papaya pulp extract and seed from seeded fruits invariably affects the sperm motility and viability since fructose serve as the driving energy of the sperms which are androgen dependent. The quality and quantity of the sperm is altered by the Carica papaya fruit extract and seed which in turn may affect reproductive potential. This can be attributed to the anti-androgenic property of the extract.
