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The success of any weed control program requires the prior identification of the sensitive phase of the crop to a grassing. In this context, field experiments were conducted during two years at Manfla (Côte d’Ivoire) to study the response of yield and its components to weeding time interruption. Two controls (negatif and positif) and three weeding time interruption (treatment 1, treatment 2 and treatment 3) were performed during the reproductive phase in three blocks design experiment. Statistical analysis indicated that treatment 1, treatment 2, treatment 3 and positif control recorded similar value of seed yield. Thus the reproductive phase of this cucurbit is not influenced by weeds. The weeding of plots for this crop can be limited to the vegetative phase to ensure it production.