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Capsicum (Capsicum annuumL.var. grossum) grows widely in many parts of the world as vegetable and is usually utilized by many communities as a nutritional additive. This study is designed to evaluate the effect of inoculation of effective microorganism (EM) on growth and yield of capsicum in poly house. It comprised of four treatments, replicated and arranged in a complete randomized design. Capsicum inoculated with effective microorganisms and organic manure recorded highest values in all the growth and yield parameters measured. The results from this study demonstrated that growth and yield of capsicum may be improved by inoculating the plants with effective microorganisms, and as a result reduce the use of fertilizers in production of this vegetable hence promoting sustainable agriculture. More studies would be needed to determine the effects of effective microorganisms’ inoculation on other capsicum species.