Background: Musculoskeletal disorders represent a significant occupational problem among nurses. It is established that nurses suffer from varying degrees of musculoskeletal disorders (MSD) in different regions of the body which results in frequent loss of work days. Nursing is a profession with high incidence and prevalence of back pain. Exclusive to this systematic review is the examination of different intervention strategies adopted to curb the occurrence of work related musculoskeletal disorders among nurses, specifically physical exercise/therapy. The aim of this study was to determine the effect of such an ergonomic and ergonomic plus physiotherapy treatment on functional and symptomatic parameters of moderately disabled nurses with chronic low back pain. Study Design: Experimental design. Methods: 30 patients (nurses) were selected randomly from the hospital and were divided into two equal groups. Both Group A &B were given ergonomic intervention for 4 weeks. And Group A was given Physiotherapy intervention for 4session/week, up to 4 weeks. Outcome Measure: VAS(Visual Analogue Scale), Oswestry low back pain disability. Result: In Group-A (Physiotherapy plus ergonomic) and Group-B (ergonomic), all data was expressed as mean ± , SD and was statistically analysed using paired ‘t’ test and independent ‘t’ test to determine the statistical difference among the parameters at 0.5% level of significance. Statistical data of VAS & Oswestry low back pain disability scores showing that, Group-A is significantly different from Group-B with p<0.05; i.e. 95% of significance. Conclusion: In this study conclude that Physiotherapy plus ergonomic intervention to give greater improvement in pain, and functional performance in chronic low back pain among nurses.