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“A study to assess the effectiveness of structured teaching program on knowledge and practice of ergonomics among selected operation theatre nurses in selected hospitals of Pune city.” The objectives were: a) To assess the knowledge and practice of ergonomics among selected operation theatre nurses before a structured teaching program, b) To assess the knowledge and practice of ergonomics after giving the structured teaching program, c) To compare the knowledge and practice of ergonomics before and after the structured teaching program,d) To associate the findings to selected demographic variables with the level of knowledge and practice of ergonomics. In this quantitative approach, a pretest post test control group design was used for 60 samples using purposive sampling technique. A structured questionnaire and an observation checklist were prepared to assess the knowledge and practices. On the first day, following the assessment of knowledge and practice, a planned teaching was given and post test was conducted after a period of 5 days to the experimental group. Findings revealed that the average knowledge score in pretest of the experimental group was 6.6 which increased to 14.1 in posttest.Average practices score in pretest was 3.5 which decreased to 1.9 in posttest. Conclusion: Structured teaching program on ergonomics was found to be significantly effective in improving the knowledge and practices of nurses working in operation theatre.