Infertility can be defined as a lack of pregnancy after one year of unprotected intercourse, and it is the manifestation of one or more pathologic conditions of male or female origin. Reduced spermatogenesis and defective sperm function are the most prevalent causes of idiopathic male infertility. Many environmental, physiologic, endocrine, and genetic factors have been reported as underlying poor sperm function and male factor infertility. At present, there is a dearth of research evaluating the use of herbal medicines as pro-fertility agents. There are many well-tested Ayurveda and other traditional herbs, which have a long standing reputation as a cure for sexual dysfunction and which have been used in numerous preparations for improving sexual performance and fertility. M. pruriens seeds & Tribulus terristris fruits have been found to be powerful aphrodisiacs and are known to promote sexual vigour and semen. Formulations containing the combination of these have shown promising results in the management and treatment of sexual disorders. The present study is aimed at demonstrating spermatogenic restorative efficacy of above herbs and its major constituent, and finding the possible mechanism of action thereof in a rat model The results thus throws light on use of ethnobotanical herbs for treatment of infertility
