Background Rheumatoid arthritis (RA) and chronic periodontitis (CP) are the most common chronic inflammatory diseases and have similar pathologies. Oxygen metabolism has an important role in the pathogenesis of both CP and RA.
Aims and objective The aims of the study are 1. To compare the salivary and serum ROM levels in Chronic periodontitis and in patients with and without Rheumatoid arthritis. 2. To clinically correlate the effect of rheumatoid arthritis on the severity and progress of chronic periodontitis.
Materials and methods The study population consisted of 90 subjects belonging to both the Sexes were randomly selected. Subjects were divided into three groups. Rheumatoid arthritis group (RA), Chronic Periodontitis (CP) without Rheumatoid arthritis and Rheumatoid arthritis with chronic periodontitis (CP+RA). Saliva and serum were collected in all the three groups to estimate the Reactive oxygen metabolite levels.
Results There was a significant increase of ROM in the RA + CP group when compared with RA and CP (p value <0.001). But there was no significant differences in salivary ROM levels between RA and CP (p value 0.28) and serum ROM levels between RA and CP (p value 0.178)
Conclusion The results of our study suggested that a significant oxidative stress occur in Chronic Periodontitis and Rheumatoid arthritis. The findings also suggest that it might play an important role in the pathogenesis of Periodontitis and Rheumatoid arthritis and the associated tissue damage.
