Vitamin D plays an important role in bone remodelling, bone hemostatis, as well as in immunity. Due to this, it might affect the extent and development of inflammatory diseases such as periodontitis and diabetes mellitus. Vitamin D deficiency leads with various disorders and the attention is given by the scientific and clinical community because of pleiotropic effects of this hormone in the skeletal system. Studies have shown that vitamin D has anti-inflammatory and antimicrobial properties and plays a important role in musculoskeletal health. There is strong evidence that vitamin D deficiency may increase the likelihood of osteoporosis and osteopenia as well as chronic inflammatory diseases such as hypertension, diabetes mellitus, cardiovascular disease, stroke, inflammatory bowel disease, periodontal disease, mental illness, and cancers.
