Peste des Petits Ruminants (PPR) is a disease of major economic importance and imposes a significant constraint upon sheep and goats production owing to its high mortality rate. A study was undertaken to find out the difference in age wise antibody response following PPR vaccination in sheep of 3 different age groups at Livestock Research Station, Palamaner, Chittoor, Andhra Pradesh state, India. For this purpose three different age groups viz., Group I sheep of 6-12 months, Group II sheep of 1-2 years and Group III sheep of above 2 years age has chosen for the study. These sheep were given 1ml reconstituted PPR vaccine subcutaneously. Six apparently healthy sheep belonging to the same farm were kept as control group (Group IV). Blood samples were collected before and after vaccination, sera were obtained and analyzed on day zero, 30, 60 and 90 for antibodies against PPR by competitive ELISA (c-ELISA). Results showed that mean Percent inhibition values in all age groups (G-I, G-II and G-III) gradually increased until 90 days (maximum period of observation) of post immunization, indicating initiation of antibody response to vaccine under field condition. No untoward reactions were observed following vaccination and also the immune response was uniform in all the age group of sheep under study. All vaccinated animals developed high titre of antibodies. Further studies are required to determine the duration of immunity of PPR live attenuated vaccine.
