Asystasia travancorica Bedd an ethnomedicinal plant was studied for its immunomodulatory activity. Immunomodulatory activity of different doses of ethanol extract of Asystasia travancorica was evaluated in Swiss albino mice. Mice were treated with two doses (200 and 400mg/kg body weight) for 5 days. Body weight, relative organ weight, delayed type hypersensitivity (DTH) response and Haemagglutinin titre (HT) were studied in various groups of animals. The results obtained show a significant increase (p<0.05) in body weight and relative organ weight of spleen, liver and kidney at dose of 400mg/kg. The Asystasia travancorica extract eliciated a significant increase (p<0.05) in the DTH response at dose of 400mg/kg. In the HT test, the plant extract showed a stimulatory effect at all doses. The doses of 400mg/kg significantly (p<0.05) increases the WBC count, compared with the control group. Overall, Asystasia travancorica showed a stimulatory effect on both humoral and cellular immune functions in animal models.
