Evaluation Of Selected Medicinal Plants For Their Potential Antimicrobial Activities Against Eskape Pathogens And The Study Of P-Glycoprotein Related Antibiosis; An Indirect Approach To Assess Efflux Mechanism

ESKAPE pathogens have significantly contributed the high mortality rate of hospital borne infections. Multidrug resistance and biofilm formation are the prime hurdles for controlling infections of ESKAPE pathogens. In vivo toxicity of the allopathic chemotherapeutic agents limits the complete eradication of ESKAPE pathogens. P-glycoprotein is one of the efflux proteins present in the plasma membrane and partially regulates multidrug resistance of ESKAPE pathogens. Certain plant extracts in processed form keeps potential to block the activities of P-glycoprotein. Present study is aimed towards exploring natural plant derived substances for the control of ESKAPE pathogens and thus keeps multidisciplinary approach.