Background and Aims: PCOS contributes to infertility. The one of infertility cause in PCOS is the poor endometrial receptivity. COX-2, MUC-1 and MMP-9 have an importance role in the embryonic implantation during adhesion, invasion and decidualization. This study intends to know the expression of COX-2, MUC-1 and MMP-9.
Methods: A case control study conducted in FertilitasSekar Clinicand Department of Obstetric Gynecology Moewardi Hospital Central of Java Indonesia. The expression of COX-2, MUC-1 and MMP-9 in endometrial biopsy LH + 5 until LH +10 which meet the inclusion and exclusion criteria was checked by immunohistochemistry. The number of samples were 40 subjects consisting of 20 PCOS patients and 20 fertile women. The data was analyzed using Mann Whitney test. Results: The mean of COX-2 expression in PCOS (16.25±34.90) in fertile women (42.05±44.15), p=0.065; MUC-1 in PCOS (65.75±44.81), in fertile women (6.80±16.33), p=≤0.001; MMP-9 in PCOS (64.00±34.66), in fertile women (4.15±13.50), p=≤ 0.001.
Conclusion: The expression of COX-2 was not significant. MUC-1 and MMP-9 were higher in PCOS than in fertile women.
