Fatty Liver And Vascular Complications In Type 2 Diabetes Mellitus

Research Article
Srinivas P.S.S and ShobaDevi K
DOI: 
xxx-xxxxx-xxxx
Subject: 
science
KeyWords: 
Fatty liver, Diabetes, vascular complications, Nephropathy and Neuropathy.
Abstract: 

Background: Among diabetic patients Fatty liver disease is of common occurance. Various studies showed that liver adiposity is independently associated with Insulin Resistance and its presence can significantly increase the risk of various micro and macrovascular complications of diabetes mellitus. Aims: Evaluating type 2 diabetes patients for micro and macrovascular complications and correlating their association with fatty liver disease in these patients. Material and methods: 141 diabetic patients admitted in a King George Hospital and Andhra medical College, Visakhapatnam of Andhra Pradesh, Indiax over a two year period were screened for fatty liver by ultrasonography of the abdomen and were classified into FL (fatty Liver) group and NFL (non fatty liver) group, with and without fatty liver, respectively. All patients were investigated for complications like nephropathy, neuropathy, retinopathy, cardiac and peripheral vascular disease. Statistical analysis was done to find the association of these complications with fatty liver. Results: Out of 141 patients, 49 (35%) had fatty liver. Leading complication was neuropathy (31.2%), followed by nephropathy (11.3 %), retinopathy (10.6 %), cardiac disease (9.2%) and peripheral vascular disease (3.55%). Between FL and NFL groups, Diabetic neuropathy (40.8% vs 23.9%) and cardiac disease (16.3% vs 5.4%) showed statical significance (p<0.05), while other complications were more or less equally prevalent in the two groups. Conclusions: Fatty liver is seen in one third of diabetic patients. Vascular complications like neuropathy and cardiac disease are more commonly seen in diabetic patients with fatty liver than those without fatty liver.