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Visha Chikitsa (Treatment of Poison) explains the action of hazardous elements on body functions and how it can destroy the body tissues. Humans are constantly exposed to potentially toxic environmental chemicals through food, environmental pollution of the air, water and soil. Visha Dravys are used in various Ayurvedic formulations, notwithstanding their reported side effects because of their sudden effectiveness and in comparatively smaller dose. Ayurveda describes many of Visha Dravyas of herbomineral or animal origin. Some specific antidotes for poisons are prescribed for abolishing its effects in Ancient Samhitas. Ancient texts such as Charaka Samhitha, Susrutha Samhitha and Ashtanga Sangraha suggest extensive information on this division of Ayurveda. Our ancient Acharya opined that a deadly poison can become a very good medicine if it is administered properly. This appraisal is a straight attempt to summarize the information regarding about poisonous and semi poisonous drugs depicted in Indian system of medicine in respect to their specific Ayurvedic treatment (Ayurvedic Antidote).