Endodontic surgery aims at the resolution of a periapical inflammatory process by surgical access followed by enucleation of the lesion and root-end filling to curb any potentially noxious agent within the physical confines of the affected root. Guided tissue regeneration could be associated with endodontic surgery aiming to enhance periradicular tissue regeneration. A barrier membrane when placed over a surgical site allows the selective proliferation of osteoprogenitor cells, and thus, good healing with bone formation, instead of fibrous tissue is obtained. This case report describes the healing process after endodontic surgery with a 6-months follow-up. The apicoectomy was followed by retrograde filling with MTA. The bone defect was filled with PerioGlas (NovaBone, Austin, TX, USA) and covered with a resorbable Guidor membrane (Sunstar, Foster Ave, Chicago, USA). The patient showed no clinical signs and symptoms on 6-month follow up and radiographic evaluation showed progressive healing of the defect at 6 months.
