Lead is one of the main environmental contaminants which can threaten the living organisms in many ways. Lead toxicity may affect multiple organs of human body and is associated with a number of physiological, biochemical, and morphological alterations. The study aimed to investigate the risk which may result from exposure to different doses of lead acetate on body and organs weight, haematological indices, and the function of liver and kidney. The experiment was performed on 80 mice aged 3 month. They maintained on standard healthy laboratory conditions and had free access to food and drinking water ad libitum. The animals were divided into four equal groups. The first group represented the healthy control animals, while group II, III, and IV were given sub-lethal doses of lead acetate (0.4, 0.8, and 1.2 mg/kg bd. wt.) in drinking water for 12 weeks. At the end of the experimental period, blood was collected and used for haematological and biochemical analysis. The results indicated that mice treated with lead acetate showed significant reduction in TEC, PCV, Hb, MCV, MCH, and MCHC compared to the healthy control ones. While there were significant elevation in TLC and platelets. The results also showed significant increase in the activities of ALT, AST, GGT, AKP, and LDH indicating liver dysfunction. In addition, the serum level of BUN and creatinine was also increased compared to the control indicating renal deficincey.
