A Prospective observational study was conducted in 105 hypertensive patients for a period of 6 months in Vivekanandha Medical Care Hospital, Elayampalayam. The enrolled patients were assessed for knowledge and awareness about hypertension using KAP questionnaire. They were divided into two groups. The adherence was assessed using Hill-Bone Adherence to Blood Pressure Therapy Scale. The collected BP levels were analyzed using GraphPad InStat 3 software. Medication adherence of 105 patients was analyzed in two groups A and B. The BP levels of both groups were collected in all review. Counseling was given for group B from baseline to review II. They showed significant reduction in BP levels. The most prescribed drug class was found to be Furosemide. The study also observed increase in number of medication results in decreased medication adherence. The association of medication adherence and BP level with respect to comorbidities showed that patients with satisfactory BP control had low percentage of having long term co-existing conditions. In this study, forgetfulness was the most commonly observed reason for non-adherence. The increase in number of medication results in decreased adherence to the therapy. Patients with poor BP control seen to have more co-morbidities associated with hypertension. Maintaining optimal BP level and medication adherence together is essential for preventing comorbidities. Focusing on the lifestyle modification will help patients to achieve an optimal BP control. The presence of pharmacist will play an essential role in maintaining medication adherence and optimal BP control in hypertensive patients by counseling.