The human immune system consists of many interdependent cell types that together defend the body from infections and prevents the growth of tumor cells. Its effective functioning depends on a balanced interplay between immune cells, their chemical mediators, and the regulatory neuro endocrine pathways. Stress tilts this balance through several mechanisms and results in impaired immunity. The purpose of this article is to explore the beneficial effects of meditation on the immune system. Based on the contemporary research, it is evident that regular practice of meditation improves the functioning of the immune system through its moderating effect on emotional, psychological and neuro endocrinal pathways. Meditation improves immunity against infections and cancer and it is an effective adjunct in the treatment of several auto immune disorders. Almost all the methods of meditation explored so far have been effective in this regard, however, strict adherence to the practice appears to be crucial. In today’s busy world, people generally require user-friendly systems. Customized adaptations of Raja Yoga system like Heartfulness meditation are simple, easy to practice and foster better adherence to derive maximum benefits.