Probiotics are often employed to bacterial pathogens control in the aquaculture systems. Beneficial probiotics such as Lactobacillus, Nitrosomonas, Nitrobacter, Bacillus and Vibirio sp. are used commercially. In the present investigation, two types of commercial probiotics were used i.e., Aqua gut (fish) as feed probiotic-treatment-2 and Nitro-PS+ Micro-Pro (fish) as soil and water probiotics treatment-3 (manufactured by Asian Bio Tech, Hyderabad, Andhra Pradesh, India). The fishponds stocked with catla (Catla catla), rohu (Labeo rohita) and grass carp (Ctenopharyngodon idella) were selected and are designated as control pond (T1), Treatment-2 and Treatment-3. Treatment 2 and 3 were treated with probiotics control pond without probiotic. In Experiments was conducted for the period of one year from August 2012 to July 2013. The review is therefore, aiming to highlight the serum IgM levels of experimental fish were higher than that of control fish. The fish with probiotics (T2 and T3) showed in the height of the epithelial layer of the villi of the middle portion of the intestine, then in control treatments.