Anti-clastogenic activity of alcoholic (LIALC) and ethyl acetate (LIEAC) fractions of root of lawsonia inermis (LI) on micronucleus (MN) formation on mice bone marrow and blood cell were studied. Mice were treated with two doses of LIALC and LIEAC (200 and 300 mg/kg) for 14 days and challenged with normal (distilled water) and CYCLO (cyclophosphamide) treated group. Mice were scarified; peripheral blood cells and bone marrow were collected. The formation of MN was calculated based on PCE/NCE (indicator of proliferation). PCE/NCE of LIEAC (200 and 300 mg/kg) in bone marrow was observed 0.55±0.27 and 0.625±0.10, and in peripheral blood cells was 0.46±0.09 and 0.5±0.87 respectively, which showed significant increase compared to CYCLO treated group. The CYCLO treated mice, showed fall in PCE/NCE ratio, however both LIALC and LIEAC, at 200 and 300 mg/kg, inhibited micronuclei formation but percentage of inhibition of MN formation was more in LIEAC at 300 mg/kg.
