The periodontal status is associated with adverse pregnancy outcomes, such as preeclampsia (PE). The aim of this study was to evaluate the possible links between PE and periodontal disease, and correlate this association with the maternal gingival crevicular fluid (GCF) interleukin (IL)-6, IL-35 and IL-37 levels and the periodontal clinical parameters. In this descriptive study, 90 pregnant women were evaluated. The patients were divided into 3 groups, as follows: healthy pregnant women (HC), pregnant women with mild PE (MP) and pregnant women with severe PE (SP). The periodontal measurements were recorded. The IL-6, IL-35 and IL-37 concentrations in the GCF were determined using an enzyme-linked immunosorbent assay. There was no statistically significant difference between the HC, MP and SP groups in terms of the periodontal parameters (p>0.05). In addition, the IL-6 and IL-37 levels did not show significant changes between the groups (p>0.05). However, the IL-35 levels were significantly decreased in the MP and SP groups when compared to the HC group(p<0.05).This study exhibited that there was no association between the periodontal status and PE. However, the results revealed a decrease in the GCF IL-35 level in PE cases.
