Aims & Objectives: Postpartum haemorrhage is defined as loss of 500ml or more of blood after the delivery of the child vaginally. The aims of the present study includes, the prevention and treatment of atonic postpartum haemorrhage by administering the intrauterine route during caesarean section. Whether to know any benefits because of the patient position need not be changed as per rectal administration, and also early administration of the drug even before the completion of surgery has got any advantage. Materials & Methods: The efficacy of intrauterine misoprostol in the dose of 600μg for the prevention and treatment of atonic postpartum haemorrhage was studied between May 2008 to November 2010 in the Department of Obstetrics and Gynaecology, Guntur Medical College, Government General Hospital, Guntur. Patients informed consent was obtained and Ethical clearance from the Hospital ethical committee. Results: Study of haemoglobin difference of antenatal mothers, Study of packed cell volume difference, Study of amount of bleeding during delivery and up to 24 hours after delivery, Study of side effects observed in antenatal mothers, Study of complications observed in the antenatal mothers, Comparision of all parameters of our study was done for both group I and group II by using student t test. Conclusion: The intrauterine misoprostol of 600 µg is effective for the prevention and treatment of atonic postpartum haemorrhage during caesarean section. It can be easily administered during caesarean section because the patient position need not be changed as for per rectal administration. Administration of the drug even before the completion of surgery is advantageous. Misoprostol because of its thermo stability and ease of administration can be a good alternative to traditional oxytocics in low risk cases of caesarean sections as well as normal vaginal deliveries. As our study shows that there are no serious side effects with intrauterine misoprostol in low risk cases of caesarean sections, it has a good scope for use in high risk pregnancies.
