The scope of this study is to establish the resistance of antimicrobial agents of Photobacteriumdamselae sub sp. piscicida strains isolated from 100 juvenile sea bass (Dicentrarhuslabrax) and 100 gilthead sea bream (Sparusaurata). A total of 21 P. damselaesubsp.piscicida strains were used in this study. These strains were identified from 12 juvenile sea bass (Dicentrarhuslabrax) samples and 9 gilthead sea bream (Sparusaurata) samples. In this research, antimicrobial resistance was tested by the microdilution method. Oxytetracycline (30 µg), cloxacillin (5 µg), enrofloxacin (5 µg), florfenicol (30 µg), cefoperaz one (5 µg) and ampicillin (10 µg) were used in the study for antimicrobial susceptibility tests. In conclusion, it isrevealed that P. damselae sub sp. piscicida isolates were resistant to cloxacillin, cefoperazone and ampicillin
